بررسی بقا بر اساس سیستم نمره‌بندی GPA در مبتلایان به متاستازهای مغزی درمان شده با رادیوسرجری گامانایف

Abstract Background: This study was done to define the role of Graded Prognostic Assessment (GPA) score for predicting overall survival in patients diagnosed with brain metastases undergoing Gamma-knife radiosurgery. Materials and methods: Patients diagnosed with brain metastases who were candidates for Gamma-knife radiosurgery entered this cross sectional study between 2003 and 2011. Clinical and radiological parameters were evaluated, and the GPA score were determined. Kaplan–Meier, log-rank, was used to assess prognostic value of the GPA score. Results: Two hundred and twenty patients were eligible to enter the study during the course of the study. Patients were aged 54 ± 12.7 years (19 to 82 years) and were followed for an average of 7 (range 1-25) months after treatment with Gamma-knife. Median survival times according to GPA were: GPA 0–1=4±0.4 months GPA 1.5–2.5=6±0.7 months GPA 3= 9±0.9 months and GPA 3.5–4.0= 12±1.8 months Mean overall survival was 7±0.6 months. The level of statistical significance between GPA groups was p < 0.0001. Conclusion: It seems that the preoperative GPA is able to predict Gamma-knife radiosurgery results in patients with brain metastases. The results will need to be confirmed with further Clinical trials. Keywords: Brain metastases, GPA Score, Gamma-knife radiosurgery, prognosis.